The Obstetrician and Gynaecologist 2000;2(3) 29-31. Introduction Obstetric Cholestasis (OC), also referred to as intrahepatic cholestasis of pregnancy, is a multifactorial condition of pregnancy. Usually it's just a bit uncomfortable, but sometimes it can be the sign of a condition called obstetric cholestasis. ... NHS Trust. Version Number: 5 1. What causes obstetric cholestasis? Any deviation from this guideline must be clearly documented, including the reason for deviation. Prevalence is influenced by genetic and environmental factors and … 1.2 This version supersedes any previous versions of this document. The cause of obstetric cholestasis is not yet understood, but it is thought that hormones and genetic and environmental factors (for example diet) may be involved. In England, obstetric cholestasis (also referred to as intrahepatic cholestasis of pregnancy) affects 0.7% of pregnancies in multiethnic populations and 1.2 –1.5% of women of Indian– Asian or Pakistani –Asian origin. Eighteen spontaneous premature deliveries occurred. Aim/Purpose of this Guideline 1.1 To give guidance to obstetricians and midwives on the management of women with Obstetric Cholestasis (OC). Obstetric Cholestasis (OC) diagnosis and management guideline Page 2 of 10 See the Intranet for the latest version. It is characterised by In the UK fewer than 1 in 100 pregnant women will develop it. What is Obstetric Cholestasis? 4.Kelly A, Nelson-Piercy C. Obstetric cholestasis:PACE review. Five mothers required specific treatment for unexplained postpartum haemorrhage. Obstetric cholestasis affects your liver, and can lead to your baby being born early or stillbirth. Palma J, Reyes H, Ribalta J et al. Many women have some itching in pregnancy. 5. 1.4. Intrahepatic cholestasis of pregnancy, commonly known as cholestasis of pregnancy, is a liver condition that occurs in late pregnancy. This document sets out Northern Devon Healthcare NHS Trust’s best guidance on the management of women presenting with Obstetric Cholestasis. The condition triggers intense itching, but without a rash. Obstetric cholestasis. Google Scholar: (obstetric cholestasis and vitamin K) 6. Obstetric Cholestasis Information Leaflet What is Obstetric Cholestasis? Among 56 pregnancies complicated by obstetric cholestasis five intrauterine deaths and one neonatal death occurred between 33 and 39 weeks, and a further six infants required urgent delivery for intrapartum asphyxia. (OBSTETRIC CHOLESTASIS).ti,ab OR (CHOLESTASIS IN PREGNANCY).ti,ab) AND (VITAMIN K).ti,ab [2014-2016] 3. Obstetric Cholestasis Diagnosis and Management Clinical Guideline V2.1 Page 2 of 12 1. Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy. Add filter for NHS website (3) ... Obstetric cholestasis is a rare condition that only affects you if you are pregnant. In-house database/ resources 4. Cholestasis means that there is a reduced flow of bile down the bile ducts in the liver. Bile acids allow ingested fatty substances to dissolve so they can be absorbed into the blood stream. Obstetric cholestasis is a multifactorial condition of pregnancy, characterised by pruritis in the absence of a skin rash with abnormal liver function tests (LFTs), neither of which has an alternative cause and both of which resolve after birth. Obstetric Cholestasis (OC) is a condition of the liver that occurs in 1 in 160 (less than 1%) pregnant women in the UK. Initial assessment for diagnosis of Obstetric Cholestasis Toxbase: Obstetric Cholestasis Treatment In Pregnancy 4. NHS Evidence: (cholestasis and pregnancy) (Vitamin K and pregnancy) (obstetric cholestasis) 5. Itching usually occurs on the hands and feet but can also affect other parts of the body. Obstetric cholestasis is more common among women of Indian- Asian or Pakistani-Asian origin, with 15 in 1000 women (1.5%) affected.